Wertheim is a town in southwestern Germany, in the state of Baden-Württemberg with a population of around 23,400. It is located on the confluence of the rivers Tauber and Main. Wertheim is best known for its landmark castle and medieval town centre.

The Main is the longest tributary of the Rhine. It rises as the White Main in the Fichtel Mountains of northeastern Bavaria and flows west through central Germany for 525 kilometres (326 mi) to meet the Rhine below Rüsselsheim, Hesse. The cities of Mainz and Wiesbaden are close to the confluence.