West Plains is a city in and the county seat of Howell County, Missouri, United States. The population was 12,184 at the 2020 census.

U.S. Route 60 (US 60) is a part of the United States Numbered Highway System that runs from Brenda, Arizona, east to Virginia Beach, Virginia. In the state of Missouri, US 60 is a main east–west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border.