West Tennessee is one of the three Grand Divisions of Tennessee that roughly comprises the western quarter of the state. The region includes 21 counties between the Tennessee and Mississippi rivers, delineated by state law. Its geography consists primarily of flat lands with rich soil and vast floodplain areas of the Mississippi River. Of the three regions, West Tennessee is the most sharply defined geographically, and is the lowest-lying. It is both the least populous and smallest, in land area, of the three Grand Divisions. Its largest city is Memphis, the state's second most populous city.

The Tennessee River is the largest tributary of the Ohio River. It is approximately 652 miles (1,049 km) long and is located in the southeastern United States in the Tennessee Valley. The river was once popularly known as the Cherokee River, among other names, as the Cherokee people had their homelands along its banks, especially in what are now East Tennessee and northern Alabama. Additionally, its tributary, the Little Tennessee River, flows into it from Western North Carolina and northeastern Georgia, where the river also was bordered by numerous Cherokee towns. Its current name is derived from the Cherokee town, Tanasi, which was located on the Tennessee side of the Appalachian Mountains.