West Union is a town in Oconee County, South Carolina, United States. Although its name suggests that it is near Union, they are approximately four counties apart. The population was 291 at the 2010 census.

Oconee County is the westernmost county in the U.S. state of South Carolina. As of the 2020 census, the population was 78,607. Its county seat is Walhalla and its largest community is Seneca. Oconee County is included in the Seneca, SC Micropolitan Statistical Area, which is also included in the Greenville-Spartanburg-Anderson, SC Combined Statistical Area. South Carolina Highway 11, the Cherokee Foothills National Scenic Highway, begins in southern Oconee County at Interstate Highway 85 at the Georgia state line.