West Vernor–Junction Historic District is a commercial historic district located along West Vernor Highway between Lansing and Cavalry in Detroit, Michigan. The district includes 160 acres (0.65 km2) and 44 buildings. The district was listed on the National Register of Historic Places in 2002.

The Most Holy Redeemer Church is located at 1721 Junction Street in Southwest Detroit, Michigan, within the West Vernor–Junction Historic District. The church was once estimated as the largest Roman Catholic parish in North America. West Vernor–Junction Historic District is adjacent to Mexicantown and contains a growing Mexican community and resurgent neighborhood.