West Virginia Route 12 is a north–south route located in the southern portion of the U.S. state of West Virginia. The southern terminus of the route is at U.S. Route 219 in Peterstown, Monroe County, less than 300 yards (270 m) from the Virginia state line. It compromises a portion of the Farm Heritage Road byway between Peterstown and West Virginia Route 122. The northern terminus of the route is at U.S. Route 60 in Alta, Greenbrier County, near Interstate 64 exit 161.

U.S. Route 219 (US 219) is a part of the U.S. Highway System that travels from Rich Creek, Virginia, to West Seneca, New York. In the U.S. state of West Virginia, the U.S. Highway travels from the Virginia state line near Peterstown to the Maryland state line near Silver Lake.