West Virginia Route 480 is a 5.64-mile-long (9.08 km) state highway in the U.S. state of West Virginia. Known for most of its length as Kearneysville Pike, the highway extends from WV 115 in Kearneysville north to the Maryland state line at the Potomac River in Shepherdstown, from where the highway continues as Maryland Route 34. The route is one of the main north–south highways of northern Jefferson County and passes through the campus of Shepherd University. WV 480 was originally established in the early 1920s as West Virginia Route 48. The highway was paved in the mid-1920s, which included a different routing through Shepherdstown. WV 48's present routing through the town was established in the late 1930s when the first James Rumsey Bridge was completed; that bridge was replaced with the current bridge in the mid-2000s. WV 48 was renumbered to WV 480 in the mid-1970s after U.S. Route 48 was established in West Virginia and Maryland.

West Virginia Route 115 (WV 115) is a state highway running north to south in West Virginia's Eastern Panhandle. The southern terminus of the route is at WV 9 near Mannings. The northern terminus is near WV 9 near Baker Heights at an intersection with Opequon Lane. The route mostly follows a previous alignment of WV 9.