Western Macedonia is one of the thirteen administrative regions of Greece, consisting of the western part of Macedonia. Located in north-western Greece, it is divided into the regional units of Florina, Grevena, Kastoria, and Kozani. With a population of approximately 255,000 people, as of 2021, the region had one of the highest unemployment rates in the European Union.

Macedonia is a geographic and former administrative region of Greece, in the southern Balkans. Macedonia is the largest and second-most-populous geographic region in Greece, with a population of 2.36 million. It is highly mountainous, with major urban centres such as Thessaloniki and Kavala being concentrated on its southern coastline. Together with Thrace, along with Thessaly and Epirus occasionally, it is part of Northern Greece. Greek Macedonia encompasses entirely the southern part of the wider region of Macedonia, making up 51% of the total area of that region. Additionally, it widely constitutes Greece's borders with three countries: Albania to the northwest, North Macedonia to the north, and Bulgaria to the northeast.