The Western Region is located in south Ghana, spreads from the Ivory Coast in the west to the Central region in the east, includes the capital and large twin city of Sekondi-Takoradi on the coast, coastal Axim, and a hilly inland area including Elubo. It includes Ghana's southernmost location, Cape Three Points, where crude oil was discovered in commercial quantities in June 2007. The region covers an area of 13,842 km2, and had a population of 2,060,585 at the 2021 Census.

Ghana, officially the Republic of Ghana, is a country in West Africa. It abuts the Gulf of Guinea and the Atlantic Ocean to the south, sharing a border with Ivory Coast in the west, Burkina Faso in the north, and Togo in the east. Ghana covers an area of 239,567 km2 (92,497 sq mi), spanning diverse biomes that range from coastal savannas to tropical rainforests. With over 32 million inhabitants, Ghana is the second-most populous country in West Africa. The capital and largest city is Accra; other significant cities include Kumasi, Tamale, and Sekondi-Takoradi.