Westinghouse Desilu Playhouse is an American television anthology series produced by Desilu Productions. The show ran on the Columbia Broadcasting System between 1958 and 1960. Three of its 48 episodes served as pilots for the 1950s television series The Twilight Zone and The Untouchables.

An anthology series is a written series, radio, television, film, or video game series that presents a different story and a different set of characters in each different episode, season, segment, or short. These usually have a different cast in each episode, but several series in the past, such as Four Star Playhouse, employed a permanent troupe of character actors who would appear in a different drama each week. Some anthology series, such as Studio One, began on radio and then expanded to television.