Wetton is a village in the Peak District National Park, North Staffordshire, at the top of the east side of the Manifold Valley. The population recorded in the 2001 Census was 157. At the time of the 2011 Census the population was recorded under Ilam. This article describes the location, some of the main features of the village, and a number of places of historical or general interest in or near the village. These include Long Low, Wetton, a prehistoric burial site unique to England.

The River Manifold is a river in Staffordshire, England. It is a tributary of the River Dove.