Wetworks is an American comic book series created by comic book artist Whilce Portacio and writer Brandon Choi. It ran for four years before ending in 1998. A second series written by Mike Carey, with Portacio returning on art duties, was started in 2006 and ended in 2008.

William "Whilce" Portacio is a Filipino American comic book writer and artist noted for his work on such titles as The Punisher, X-Factor, Uncanny X-Men, Iron Man, Wetworks and Spawn. Portacio was also one of the seven co-founders of Image Comics, though he did not become a full-partner in the company, and is therefore not a member of its board of directors.