What Makes Sammy Run? (1941) is a novel by Budd Schulberg inspired by the life of his father, early Hollywood mogul B. P. Schulberg. It is a rags to riches story chronicling the rise and fall of Sammy Glick, a Jewish boy born in New York's Lower East Side who, very early in his life, makes up his mind to escape the ghetto and climb the ladder of success by deception and betrayal. It was made into a 1965 Broadway musical.

Budd Schulberg was an American screenwriter, television producer, novelist and sports writer. He was known for his novels What Makes Sammy Run? (1941) and The Harder They Fall (1947), as well as his screenplays for On the Waterfront (1954) and A Face in the Crowd (1957), receiving an Academy Award for the former.