The Wheatbelt is one of nine regions of Western Australia defined as administrative areas for the state's regional development, and a vernacular term for the area converted to agriculture during colonisation. It partially surrounds the Perth metropolitan area, extending north from Perth to the Mid West region, and east to the Goldfields–Esperance region. It is bordered to the south by the South West and Great Southern regions, and to the west by the Indian Ocean, the Perth metropolitan area, and the Peel region. Altogether, it has an area of 154,862 square kilometres (59,793 sq mi).

Great Northern Highway is an Australian highway that links Western Australia's capital city Perth with its northernmost port, Wyndham. With a length of almost 3,200 kilometres (2,000 mi), it is the longest highway in Australia, with the majority included as part of the Perth Darwin National Highway. The highway, which travels through remote areas of the state, is constructed as a sealed, predominantly two-lane single carriageway, but with some single-lane bridges in the Kimberley. Economically, it provides vital access through the Wheatbelt and Mid West to the resource-rich regions of the Pilbara and Kimberley. In these areas, the key industries of mining, agriculture and pastoral stations, and tourism are all dependent on the highway.