The Wheeling, WV–OH Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in the Northern Panhandle of West Virginia and one in eastern Ohio, anchored by the city of Wheeling. As of the 2010 census, the MSA had a population of 147,950. This represents a decline of 3.4% from the 2000 census population of 153,172.

Wheeling is a city in the U.S. state of West Virginia. Located almost entirely in Ohio County, of which it is the county seat, it lies along the Ohio River in the foothills of the Appalachian Mountains and also contains a tiny portion extending into Marshall County. Wheeling is located about 60 miles (96 km) west of Pittsburgh and is the principal city of the Wheeling metropolitan area. As of the 2020 census, the city had a population of 27,062, and the metro area had a population of 139,513. It is the fifth most populous city in West Virginia, and the most populous in the state’s Northern Panhandle.