The White House COVID-19 Response Team was the task force during the presidency of Joe Biden to respond to the COVID-19 pandemic in the United States. It was set up by Joe Biden on his first day in office – January 20, 2021 – and replaced President Trump's White House Coronavirus Task Force and Joe Biden's transitional COVID-19 Advisory Board.

Joe Biden's tenure as the 46th president of the United States began with his inauguration on January 20, 2021. Biden, a Democrat from Delaware who previously served as vice president for two terms under President Barack Obama, took office following his victory in the 2020 presidential election over Republican incumbent president Donald Trump. Upon his inauguration, he became the oldest president in American history, breaking the record set by Ronald Reagan. Biden entered office amid the COVID-19 pandemic, an economic crisis, and increased political polarization.