"Who's That Girl?" is the first single taken from American rapper Eve's second album, Scorpion (2001), released as her fifth US single in February 2001 and as her debut single in Europe. The song peaked at number 47 on the US Billboard Hot 100 and number six in the United Kingdom. VH1 ranked it at number 97 on their "100 Greatest Songs of Hip Hop" list.

Eve Jihan Cooper is an American rapper, singer, and actress from Philadelphia, Pennsylvania. Her debut studio album, Let There Be Eve...Ruff Ryders' First Lady (1999) peaked atop the Billboard 200, received double platinum certification by the Recording Industry Association of America (RIAA), and spawned the hit singles "What Ya Want", "Love Is Blind", and "Gotta Man". That same year, she guest featured on the Roots' Grammy Award-winning single "You Got Me", as well as Missy Elliott's single "Hot Boyz", both of which peaked within the top 40 of the Billboard Hot 100.