Who's That Girl is the first soundtrack album by American singer and songwriter Madonna. It was released on July 21, 1987, by Sire Records to promote the film of the same name. It also contains songs by her label mates Scritti Politti, Duncan Faure, Club Nouveau, Coati Mundi and Michael Davidson. The soundtrack is credited as a Madonna album, despite her only performing four of the nine tracks on the album. After the commercial success of the film Desperately Seeking Susan (1985), in which she co-starred, Madonna wanted to act in another comedy film titled Slammer, about a woman named Nikki Finn who was falsely accused of homicide. However, due to the critical and commercial failure of her adventure film Shanghai Surprise (1986), Warner Bros. was initially reluctant to greenlight the project but later agreed.

Who's That Girl is a 1987 American screwball comedy film directed by James Foley, and written by Andrew Smith and Ken Finkleman. It stars Madonna and Griffin Dunne, and depicts the story of a street-smart girl who is falsely accused of murdering her boyfriend and is sent to jail. After release, she meets a man, supposed to make sure she gets on her bus back to Philadelphia, and convinces him to help her catch those responsible for her confinement. While searching for an embezzler, they fall in love with each other.