Wiesbaden Hauptbahnhof is a railway station for the city of Wiesbaden, the state capital of the German state of Hesse. It is a terminal station at the southern edge of the city centre and is used by more than 40,000 travelers each day, so it is the second largest station in Hesse after Frankfurt Hauptbahnhof. It is classified by Deutsche Bahn as a category 2 station.

Wiesbaden is the capital of the German state of Hesse, and the second-largest Hessian city after Frankfurt am Main. With around 283,000 inhabitants, it is Germany's 24th-largest city. Wiesbaden forms a conurbation with a population of around 500,000 with the neighbouring city of Mainz. This conurbation is in turn embedded in the Rhine-Main Metropolitan Region—Germany's second-largest metropolitan region after Rhine-Ruhr—which also includes the nearby cities of Frankfurt am Main, Darmstadt, Offenbach am Main, and Hanau, and has a combined population exceeding 5.8 million.