Wilkesboro is a town in and the county seat of Wilkes County, North Carolina, United States. The population was 3,687 at the 2020 census. The town is located along the south bank of the Yadkin River, directly opposite the town of North Wilkesboro. Wilkesboro is a Small Town Main Street community and has recently revitalized its historic downtown to include the Carolina West Wireless Community Commons, Wilkes Communications Pavilion, Heritage Square and Splash Pad. Cub Creek Park is adjacent to the downtown and contains many amenities, which include baseball, walking trails, mountain biking trails, trout fishing, dog park, basketball, tennis, and pickleball courts, picnic shelters, etc. Wilkesboro is also the home of the annual MerleFest, Carolina in the Fall, and Brushy Mountain Peach & Heritage festivals.

Wilkes County is a county located in the U.S. state of North Carolina. It is a part of the state's western mountain region. As of the 2020 census the population was 65,969. Its county seat is Wilkesboro, and its largest community is North Wilkesboro. Wilkes County comprises the North Wilkesboro, NC Micropolitan Statistical Area.