Willamette University College of Medicine is a former school of medicine that was part of Willamette University. Founded in 1867 as the first medical school in Oregon, the school relocated between Portland and the main university campus in Salem several times. The school was merged with the University of Oregon's medical school in Portland in 1913. That school later became Oregon Health & Science University.

Willamette University is a private liberal arts college with locations in Salem and Portland, Oregon. Founded in 1842, it is the oldest college in the Western United States. Originally named the Oregon Institute, the school was an unaffiliated outgrowth of the Methodist Mission. The name was changed to Wallamet University in 1852, followed by the current spelling in 1870. Willamette founded the first medical school and law school in the Pacific Northwest in the second half of the 19th century.