William "Froggie" James, an African-American man, was lynched and his dead body mutilated on November 11, 1909 by a mob in Cairo, Illinois, after he was charged with the rape and murder of 23-year-old shop clerk Anna Pelley.

Cairo is the southernmost city in Illinois and the county seat of Alexander County. A river city, Cairo has the lowest elevation of any location in Illinois and is the only Illinois city to be surrounded by levees. It is in the river-crossed area of Southern Illinois known as "Little Egypt", for which the city is named, after Egypt's capital on the Nile. The city is coterminous with Cairo Precinct.