Dr William Alexander Francis Browne (1805–1885) was one of the most significant British asylum doctors of the nineteenth century. At Montrose Asylum (1834–1838) in Angus and at the Crichton Royal in Dumfries (1838–1857), Browne introduced activities for patients including writing, group activity and drama, pioneered early forms of occupational therapy and art therapy, and initiated one of the earliest collections of artistic work by patients in a psychiatric hospital. In an age which rewarded self-control, Browne encouraged self-expression and may therefore be counted alongside William Tuke, Vincenzo Chiarugi and John Conolly as one of the pioneers of the moral treatment of mental illness. Sociologist Andrew Scull has identified Browne's career with the institutional climax of nineteenth century psychiatry."Browne was one of the reformers of the asylum care of the insane whose improvements and innovations were chronicled in his annual reports from The Crichton Royal Institution, but who in addition published almost on the threshold of his career a sort of manifesto of what he wished to see accomplished...." Richard Hunter and Ida Macalpine (1963) Three Hundred Years of Psychiatry 1535–1860, page 865.

The Edinburgh Phrenological Society was founded in 1820 by George Combe, an Edinburgh lawyer, with his physician brother Andrew Combe. The Edinburgh Society was the first and foremost phrenology grouping in Great Britain; more than forty phrenological societies followed in other parts of the British Isles. The Society's influence was greatest over its first two decades and declined in the 1840s; the final meeting was recorded in 1870.