The Blount Mansion, also known as William Blount Mansion, located at 200 West Hill Avenue in downtown Knoxville, Tennessee, was the home of the only territorial governor of the Southwest Territory, William Blount (1749–1800). Blount, a Founding Father of the United States, a signer of the United States Constitution, and a U.S. Senator from Tennessee, lived on the property with his family and ten African-American slaves. The mansion served as the de facto capitol of the Southwest Territory. In 1796, much of the Tennessee Constitution was drafted in Governor Blount's office at the mansion. Tennessee state historian John Trotwood Moore once called Blount Mansion "the most important historical spot in Tennessee."

William Blount was an American politician, landowner and Founding Father who was one of the signers of the Constitution of the United States. He was a member of the North Carolina delegation at the Constitutional Convention of 1787 and led the efforts for North Carolina to ratify the Constitution in 1789 at the Fayetteville Convention. He then served as the only governor of the Southwest Territory and played a leading role in helping the territory gain admission to the union as the state of Tennessee. He was selected as one of Tennessee's initial United States Senators in 1796, serving until he was expelled for treason in 1797.