William Cabell Bruce was an American politician and Pulitzer Prize-winning writer who represented the State of Maryland in the United States Senate from 1923 to 1929.

The 1922 United States Senate elections were elections that occurred in the middle of Republican President Warren G. Harding's term. The 32 seats of Class 1 were contested in regular elections, and special elections were held to fill vacancies. With the Republicans divided between conservative and progressive factions, the Democrats gained six net seats from the Republicans while the Farmer–Labor party gained one. The Republicans retained their Senate majority.