The William F. Walsh Regional Transportation Center (RTC) is an Amtrak intermodal transit station serving the Syracuse area. It is owned and operated by Intermodal Transportation Center, Inc, a subsidiary of Centro, and is also served by Greyhound Lines, Megabus, and Trailways. Local and regional bus transportation is provided by Centro. Various taxi firms provide service to the Center, as well.

The Central New York Regional Transportation Authority, commonly referred to as Centro, is a New York State public benefit corporation and the operator of mass transit in Onondaga, Oswego, Cayuga, and Oneida counties in New York state. The CNYRTA was formed on August 1, 1970, along with similar agencies in Rochester, Albany, and Buffalo.