William Gibbons Preston was an American architect who practiced during the last third of the nineteenth century and in the first decade of the twentieth. Educated at Harvard University and the École des Beaux-Arts in Paris, he was active in Boston, New York, Rhode Island, Ohio, New Brunswick and Savannah, Georgia, where he was brought by George Johnson Baldwin to design the Chatham County courthouse. Preston stayed in Savannah for several years during which time designed the original Desoto Hotel, the Savannah Volunteer Guards Armory and 20 other distinguished public buildings and private homes. He began his professional career working for his father, the builder and architect Jonathan Preston (1801–1888), upon his return to the United States from the École in 1861, and was the sole practitioner in the office from the time his father retired c. 1875 until he took John Kahlmeyer as a partner in about 1885.

The Walter E. Fernald State School, later the Walter E. Fernald Developmental Center, was the Western hemisphere's oldest publicly funded institution serving people with developmental disabilities. Originally a Victorian sanatorium, it became a "poster child" for the American eugenics movement during the 1920s. It later was the scene of medical experiments in the 20th century. Investigations into this research led to new regulations regarding human research in children.