William George McCloskey was an American Catholic priest, who became the fourth Bishop of Louisville, Kentucky.

The Archdiocese of Louisville is a Latin Church ecclesiastical territory, or archdiocese, of the Catholic Church in central Kentucky in the United States. The cathedral church of the archdiocese is the Cathedral of the Assumption in Louisville, Kentucky. The archdiocese is the seat of the metropolitan see of the Province of Louisville, which encompasses the states of Kentucky and Tennessee. The archdiocese is the second-oldest diocese west of the Appalachian Mountains, after the Archdiocese of New Orleans. As of 2023, the archbishop of Louisville is Shelton Fabre.