William Edward Hickey was an American actor. He is best known for his Academy Award-nominated role as Don Corrado Prizzi in the John Huston film Prizzi's Honor (1985), as well as Uncle Lewis in National Lampoon's Christmas Vacation (1989) and the voice of Dr. Finkelstein in Tim Burton's The Nightmare Before Christmas (1993).

Prizzi's Honor is a 1985 American black comedy crime film directed by John Huston, starring Jack Nicholson and Kathleen Turner as two highly skilled mob assassins who, after falling in love, are hired to kill each other. The screenplay co-written by Richard Condon is based on his 1982 novel of the same name. The film's supporting cast includes Anjelica Huston, Robert Loggia, John Randolph, CCH Pounder, Lawrence Tierney, and William Hickey. Stanley Tucci appears in a minor role in his film debut. It was the last of John Huston's films to be released during his lifetime.