William McSherry was an American Catholic priest and Jesuit who became the president of Georgetown College and a Jesuit provincial superior. The son of Irish immigrants, McSherry was educated at Georgetown College, where he entered the Society of Jesus. As one of the first Americans to complete the traditional Jesuit course of training, he was sent to Rome to be educated for the priesthood. There, he made several discoveries of significant, forgotten holdings in the Jesuit archives, which improved historians' knowledge of the early European settling of Maryland and of the language of Indian tribes there.

The Jesuits in the United States constitute the American branch of the Society of Jesus and are organized into four geographic provinces — East, Central and Southern, Midwest and West — each of which is headed by a provincial superior. The order is known, historically, for its missions to the Native Americans in the early 17th century, for owning and participating in the Atlantic slave trade, and, contemporarily, for its network of colleges and universities across the country.