William Sandys, 1st Baron Sandys, KG, of The Vyne in the parish of Sherborne St John, Hampshire, was an English diplomat, and a favourite of King Henry VIII, whom he served as Lord Chamberlain. In the 1520s he built a palatial Tudor-style mansion at "The Vyne", which survives in a reduced and classicised form as a possession of the National Trust.

The Vyne is a Grade I listed 16th-century country house in the parish of Sherborne St John, near Basingstoke, in Hampshire, England. The house was first built circa 1500–10 in the Tudor style by William Sandys, 1st Baron Sandys, Lord Chamberlain to King Henry VIII. In the 17th century it was transformed to resemble a classical mansion. Today, although much reduced in size, the house retains its Tudor chapel, with contemporary stained glass. The classical portico on the north front was added in 1654 to the design of John Webb, a pupil of Inigo Jones, and is notable as the first portico in English domestic architecture.