Williamsburg County is a county located in the U.S. state of South Carolina. As of the 2020 census its population was 31,026. The county seat and largest community is Kingstree. After a previous incarnation of Williamsburg County, the current county was created in 1804.

South Carolina's 6th congressional district is in central and eastern South Carolina. It includes all of Allendale, Bamberg, Calhoun, Clarendon, Hampton, and Williamsburg counties and parts of Charleston, Colleton, Dorchester, Florence, Jasper, Orangeburg, Richland and Sumter counties. With a Cook Partisan Voting Index rating of D+14, it is the only Democratic district in South Carolina.