The Victorian government's Wimmera Southern Mallee subregion is part of the Grampians region in western Victoria. It includes most of what is considered the Wimmera, and part of the southern Mallee region. The subregion is based on the social catchment of Horsham, its main settlement.

The Grampians is an economic rural region located in the western part of Victoria, Australia. The 48,646-square-kilometre (18,782 sq mi) region lies to the northwest of the western suburbs of Greater Melbourne, to the state's western border with South Australia and includes the Grampians National Park and significant gold mining heritage assets. The Grampians region has two sub-regions: the Central Highlands and Wimmera Southern Mallee.