Winston-Salem State University (WSSU) is a historically black public university in Winston-Salem, North Carolina. It is part of the University of North Carolina system.

Historically black colleges and universities (HBCUs) are institutions of higher education in the United States that were established before the Civil Rights Act of 1964 with the intention of primarily serving African Americans. Most of these institutions were founded during the Reconstruction era after the Civil War and are concentrated in the Southern United States. They were primarily founded by Protestant religious groups, until the Second Morill Act of 1890 required educationally segregated states to provide African American, public higher-education schools in order to receive the Act's benefits.