The Wiscasset Historic District is a 101-acre (41 ha) historic district that encompasses substantially all of the central village of Wiscasset, Maine. The district includes at least 22 contributing buildings and two other contributing sites, one being a cemetery whose oldest stone is from 1739. Located on the west bank of the Sheepscot River and settled in the 18th century, Wiscasset was a prominent harbor in Mid Coast Maine, and a major shipbuilding and merchant port, until the War of 1812 ended its prosperity. The village center includes fine examples of Federal period architecture, most built between about 1780 and 1820, including one National Historic Landmark, the Nickels-Sortwell House. The district was listed on the National Register of Historic Places in 1973.

The Nickels-Sortwell House is a historic house museum at 121 Main Street in Wiscasset, Maine, United States. Built in 1807 by a wealthy ship's captain, the house was designated a National Historic Landmark in 1970 as an exceptionally high-quality example of the Federal style of architecture. After serving as a hotel for much of the 19th century, the house returned to private hands in 1900. It was given to Historic New England in 1958, which gives tours of the house between May and October.