The 10th Senate district of Wisconsin is one of 33 districts in the Wisconsin Senate. Located in northwest Wisconsin, the district comprises all of Buffalo, Pepin, Pierce, and St. Croix counties, along with most of Trempealeau and parts of western Dunn County. It continas the cities of Hudson, Arcadia, New Richmond, Prescott, Mondovi, Blair, Independence, Buffalo City, Fountain City, and River Falls. It also contains landmarks such as Kinnickinnic State Park, Perrot State Park, Trempealeau National Wildlife Refuge, and part of the Saint Croix National Scenic Riverway.

The Wisconsin Senate is the upper house of the Wisconsin State Legislature. Together with the larger Wisconsin State Assembly they constitute the legislative branch of the state of Wisconsin. The powers of the Wisconsin Senate are modeled after those of the U.S. Senate.