The 10th Senate district of Wisconsin is one of 33 districts in the Wisconsin Senate. Located in northwest Wisconsin, the district comprises all of Buffalo, Pepin, Pierce, and St. Croix counties, along with most of Trempealeau and parts of western Dunn County. It continas the cities of Hudson, Arcadia, New Richmond, Prescott, Mondovi, Blair, Independence, Buffalo City, Fountain City, and River Falls. It also contains landmarks such as Kinnickinnic State Park, Perrot State Park, Trempealeau National Wildlife Refuge, and part of the Saint Croix National Scenic Riverway.

The First Wisconsin Legislature convened from June 5, 1848, to August 21, 1848, in regular session. Members of the Assembly and Senate were elected after an election on February 1, 1848, that ratified the proposed state constitution.