The 22nd Senate District of Wisconsin is one of 33 districts in the Wisconsin Senate. Located in southeast Wisconsin, the district comprises parts of eastern Kenosha County and southeast Racine County, including most of the city of Kenosha and the south side of the city of Racine, along with the villages of Somers and Sturtevant, most of the village of Mount Pleasant, and the northern half of the village of Pleasant Prairie. The district also contains Kenosha Regional Airport, Johnson Wax Headquarters, the Foxconn in Wisconsin industrial park, Regency Mall, Carthage College, and the University of Wisconsin–Parkside campus.

The Wisconsin Senate is the upper house of the Wisconsin State Legislature. Together with the larger Wisconsin State Assembly they constitute the legislative branch of the state of Wisconsin. The powers of the Wisconsin Senate are modeled after those of the U.S. Senate.