The Wisconsin River is a tributary of the Mississippi River in the U.S. state of Wisconsin. At approximately 430 miles long, it is the state's longest river. The river's name was first recorded in 1673 by Jacques Marquette as "Meskousing", which is rooted in the Algonquian languages used by the area's Native American tribes. The river's original meaning is obscure, but French explorers who followed in the wake of Marquette later modified the name to "Ouisconsin", and so it appears on Guillaume de L'Isle's map. This was simplified to "Wisconsin" in the early 19th century, before being applied to Wisconsin Territory and finally the state of Wisconsin.

The Mississippi River is the primary river, and second-longest river, of the largest drainage basin in the United States. From its traditional source of Lake Itasca in northern Minnesota, it flows generally south for 2,340 miles (3,766 km) to the Mississippi River Delta in the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains all or parts of 32 U.S. states and two Canadian provinces between the Rocky and Appalachian mountains. The main stem is entirely within the United States; the total drainage basin is 1,151,000 sq mi (2,980,000 km2), of which only about one percent is in Canada. The Mississippi ranks as the thirteenth-largest river by discharge in the world. The river either borders or passes through the states of Minnesota, Wisconsin, Iowa, Illinois, Missouri, Kentucky, Tennessee, Arkansas, Mississippi, and Louisiana.