Wise is a town in Wise County, Virginia. The population was 3,286 at the 2010 census. It is the county seat of Wise County. It was originally incorporated as the town of Gladeville in 1874. The town's name was changed to Wise in 1924, after Henry A. Wise, the last Virginia governor before the American Civil War and the first governor to hail from the Eastern Shore of Virginia.

Wise County is a county located in the U.S. state of Virginia. The county was formed in 1856 from Lee, Scott, and Russell Counties and named for Henry A. Wise, who was the Governor of Virginia at the time. The county seat is in Wise.