Wittenberg is an unincorporated community in Brazeau Township in eastern Perry County, Missouri, United States. It is located on the Mississippi River, 14 miles (23 km) southeast of Perryville. Wittenberg is situated in the Brazeau Bottoms on Brazeau Creek opposite Grand Tower, Illinois, and Tower Rock, the latter a landmark island in the Mississippi River.

Perry County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 18,956. Its county seat is Perryville. The county was officially organized on November 16, 1820 from Ste. Genevieve County and was named after Oliver Hazard Perry, a naval hero of the War of 1812.