Worcester v. Georgia, 31 U.S. 515 (1832), was a landmark case in which the United States Supreme Court vacated the conviction of Samuel Worcester and held that the Georgia criminal statute that prohibited non-Native Americans from being present on Native American lands without a license from the state was unconstitutional. The opinion is most famous for its dicta, which laid out the relationship between tribes and the state and federal governments. It is considered to have built the foundations of the doctrine of tribal sovereignty in the United States.

Samuel Austin Worcester, was an American missionary to the Cherokee, translator of the Bible, printer, and defender of the Cherokee sovereignty. He collaborated with Elias Boudinot (Cherokee) in Georgia to establish the Cherokee Phoenix, the first Native American newspaper, which was printed in both English and the Cherokee syllabary. The Cherokee gave Worcester the honorary name A-tse-nu-sti, which translates to "messenger" in English.