The Wren Building is the oldest building on the campus of the College of William & Mary in Williamsburg, Virginia. Along with the Brafferton and President's House, these buildings form the College's "Ancient Campus." With a construction history dating to 1695, it is the oldest academic building still standing in the United States and among the oldest buildings in Virginia. It was designated a National Historic Landmark in 1960.

The College of William & Mary has maintained a campus in what is now Williamsburg, Virginia, since 1693. The cornerstone of the Wren Building, then known as the College Building and the oldest surviving academic building in the United States, was laid in 1695. The college's 18th-century campus includes the College Building, the President's House, and Brafferton–all of which were constructed using slave labor. These buildings were altered and damaged during the succeeding centuries before receiving significant restorations by the Colonial Williamsburg program during the 1920s and 1930s.