The Wren Building is the oldest building on the campus of the College of William & Mary in Williamsburg, Virginia. Along with the Brafferton and President's House, these buildings form the College's "Ancient Campus." With a construction history dating to 1695, it is the oldest academic building still standing in the United States and among the oldest buildings in Virginia. It was designated a National Historic Landmark in 1960.

The College of William & Mary in Virginia, is a public research university in Williamsburg, Virginia. Founded in 1693 under a royal charter issued by King William III and Queen Mary II, it is the second-oldest institution of higher education in the United States and the ninth-oldest in the English-speaking world. It is classified among "R2: Doctoral Universities – High Research Activity". In his 1985 book Public Ivies: A Guide to America's Best Public Undergraduate Colleges and Universities, Richard Moll included William & Mary as one of the original eight "Public Ivies". The university is also one of the original nine colonial colleges.