The Wupper-Express is a Regional-Express service in the German state of North Rhine-Westphalia (NRW) running between Aachen and Dortmund via Mönchengladbach, Düsseldorf, Wuppertal and Hagen. It is the third most widely used Regional-Express line in the area administered by the Verkehrsverbund Rhein-Ruhr (VRR) with approximately 24,000 passengers a day. The line is part of the Rhein-Ruhr-Express (RRX) network and is operated by National Express Germany.

Dortmund Hauptbahnhof is the main railway station in Dortmund, North Rhine-Westphalia, Germany. The station's origins lie in a joint station of the Köln-Mindener Eisenbahn and Bergisch-Märkische Eisenbahn which was built north of the city centre in 1847. That station was replaced by a new station, erected in 1910 at the current site. It featured raised embankments to allow a better flow of traffic. At the time of its opening, it was one of the largest stations in Germany. It was, however, destroyed in an Allied air raid on 6 October 1944.