Wuppertal-Oberbarmen station is located in the city of Wuppertal in the German state of North Rhine-Westphalia. Historically, it served as a significant railway junction, connecting to four railway lines. Presently, the station is served by two remaining lines: the Dortmund–Wuppertal main line and the branch line to Solingen.

The Wupper-Express is a Regional-Express service in the German state of North Rhine-Westphalia (NRW) running between Aachen and Dortmund via Mönchengladbach, Düsseldorf, Wuppertal and Hagen. It is the third most widely used Regional-Express line in the area administered by the Verkehrsverbund Rhein-Ruhr (VRR) with approximately 24,000 passengers a day. The line is part of the Rhein-Ruhr-Express (RRX) network and is operated by National Express Germany.