Wyalusing is a borough in Bradford County, Pennsylvania, United States. It is part of Northeastern Pennsylvania. The population was 596 as of the 2010 census.

Bradford County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, its population was 59,967. Its county seat is Towanda. The county was created on February 21, 1810, from parts of Lycoming and Luzerne Counties. Originally called Ontario County, it was reorganized and separated from Lycoming County on October 13, 1812, and renamed Bradford County for William Bradford, who had been a chief justice of the Pennsylvania Supreme Court and United States Attorney General. The county is part of the Northeast Pennsylvania region of the state.