Wyatt is a city in Mississippi County, Missouri, United States. The population was 219 at the 2020 census, down from 319 in 2010. It is the easternmost city west of the Mississippi River.

Mississippi County is a county located in the Bootheel of the U.S. state of Missouri, with its eastern border formed by the Mississippi River. As of the 2020 census, the population was 12,577. The largest city and county seat is Charleston. The county was officially organized on February 14, 1845, and was named after the Mississippi River.