Wye River is a small town in Victoria, Australia. It is also the name given to the waterway which flows through the town and into the sea. Situated 155 km to the west of Melbourne, on the Otway Coast, part of the scenic Great Ocean Road, the Wye River township is located about 15 km west of the resort town Lorne, Victoria. It became more feasible for Melburnians to holiday there after the section of the Great Ocean Road from Lorne to Apollo Bay was opened in 1932. At the 2016 census, Wye River had a permanent population of 66, although its holiday population is ten times that.

The Great Ocean Road is an Australian National Heritage-listed 240-kilometre (150 mi) stretch of road along the south-eastern coast of Australia, between the Victorian towns of Torquay and Allansford. Built by returned soldiers between 1919 and 1932, and dedicated to soldiers killed during World War I, the road is the world's largest war memorial. Winding through varying terrain along the coast, and providing access to several prominent landmarks, including the Twelve Apostles limestone stack formations, the road is an important tourist attraction.