Wylie House is a historic structure built in 1835 and located in Bloomington, Indiana. It was home of Andrew Wylie, first president of Indiana University, until his death in 1851. In 1859, following the death of Andrew's widow Margaret, Theophilus Adam Wylie, professor at Indiana University and half-cousin to Andrew, purchased the house from their heirs and his family resided there until his widow's death in 1913. Today Wylie House is operated as an historic house museum by Indiana University Libraries to interpret the lives of these families.

Bloomington is a city in and the county seat of Monroe County, Indiana, United States. The population was 79,168 at the 2020 census. It is the seventh-most populous city in Indiana and the fourth-most populous outside the Indianapolis metropolitan area. It is the home of Indiana University Bloomington, the flagship campus of the Indiana University system. Established in 1820, IU Bloomington enrolls over 45,000 students.