Wylye is a village and civil parish on the River Wylye in Wiltshire, England. The village is about 9+1⁄2 miles (15 km) northwest of Salisbury and a similar distance southeast of Warminster.

The River Wylye is a chalk stream in the south of England, with clear water flowing over gravel. It is popular with anglers for fly fishing. A half-mile stretch of the river and three lakes in Warminster are a local nature reserve.