Wyoming Seminary, founded in 1844, is a Methodist college preparatory school located in the Wyoming Valley of Northeastern Pennsylvania. The "Lower School," which consists of preschool - 8th-grade students, is located in Forty Fort. The "Upper School," comprising 9th-grade to postgraduate students, is located in Kingston. It is near the Susquehanna River and the city of Wilkes-Barre. Locally and in some publications, it is sometimes referred to as "Sem." As a boarding school, only Upper School students may board on campus. Slightly more than one-third of the Upper School student body resides on campus.

Northeastern Pennsylvania is a region of the U.S. state of Pennsylvania that includes the Pocono Mountains, the Endless Mountains, and the industrial cities of Scranton, Wilkes-Barre, Pittston, Hazleton, Nanticoke, and Carbondale. A portion of this region is located in the New York City metropolitan area. Recently, Pennsylvania tourism boards have described Northeastern Pennsylvania as Upstate Pennsylvania.